Cell shape regulates subcellular organelle location to control early Ca2+ signal dynamics in vascular smooth muscle cells
Abstract The shape of the cell is connected to its function; however, we do not fully understand underlying mechanisms by which global shape regulates a cell’s functional capabilities. Using theory, experiments and simulation, we investigated how physiologically relevant cell shape changes affect su...
Main Authors: | R. C. Calizo, M. K. Bell, A. Ron, M. Hu, S. Bhattacharya, N. J. Wong, W. G. M. Janssen, G. Perumal, P. Pederson, S. Scarlata, J. Hone, E. U. Azeloglu, P. Rangamani, R. Iyengar |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-10-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-74700-x |
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