Synthesis and Biological Evaluation of Zeise’s Salt Derivatives with Acetylsalicylic Acid Substructure

Synthesis and Biological Evaluation of Zeise’s Salt Derivatives with Acetylsalicylic Acid Substructure

The development of novel biologically active organometallic compounds bearing an acetylsalicylic acid (ASA) substructure led to the synthesis of analogical Zeise-type salts that accordingly inhibit cyclooxygenase (COX) enzymes. In order to determine the influence of the length of the alkyl chain bet...

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Bibliographic Details
Main Authors: Alexander Weninger, Daniel Baecker, Victoria Obermoser, Dorothea Egger, Klaus Wurst, Ronald Gust
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
anticancer
antiproliferative activity
capillary electrophoresis
COX inhibition
cyclooxygenase enzyme
platinum chemistry
Zeise’s salt
Online Access:http://www.mdpi.com/1422-0067/19/6/1612

Internet

http://www.mdpi.com/1422-0067/19/6/1612

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