Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and inducti...

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Bibliographic Details
Main Authors: Yu-San Huoh, Bin Wu, Sehoon Park, Darren Yang, Kushagra Bansal, Emily Greenwald, Wesley P. Wong, Diane Mathis, Sun Hur
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15448-w

Internet

https://doi.org/10.1038/s41467-020-15448-w

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