Translation of upstream open reading frames in a model of neuronal differentiation

Translation of upstream open reading frames in a model of neuronal differentiation

Abstract Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling (RP) studies suggest that translating ribosomes are pervasive within 5′...

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Bibliographic Details
Main Authors: Caitlin M. Rodriguez, Sang Y. Chun, Ryan E. Mills, Peter K. Todd
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Genomics
Subjects:
Translation
Ribosome profiling
Upstream open reading frame
Near-cognate start codon
5′ untranslated region
Neuronal differentiation
Online Access:http://link.springer.com/article/10.1186/s12864-019-5775-1

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http://link.springer.com/article/10.1186/s12864-019-5775-1

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