Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, IKs, which contributes to the repolarization phase of the cardiac action potential. A three amino acid motif (F57-T58-...

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Bibliographic Details
Main Authors: Georg Kuenze, Carlos G Vanoye, Reshma R Desai, Sneha Adusumilli, Kathryn R Brewer, Hope Woods, Eli F McDonald, Charles R Sanders, Alfred L George Jr, Jens Meiler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
KCNQ1
KCNE1
long QT syndrome
voltage-gated potassium ion channel
Rosetta
molecular dynamics simulation
Online Access:https://elifesciences.org/articles/57680

Internet

https://elifesciences.org/articles/57680

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