Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses

Abstract Background The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to study how the network responds to various...

Full description

Bibliographic Details
Main Authors: Katherine E. Larrimore, Natalia S. Barattin-Voynova, David W. Reid, Davis T. W. Ng
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Biology
Subjects:
Proteostasis
Aneuploidy
Protein homeostasis
Proteotoxic stress
Protein quality control
Online Access:http://link.springer.com/article/10.1186/s12915-020-00852-x

Internet

http://link.springer.com/article/10.1186/s12915-020-00852-x

Similar Items