Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes

Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes

Microvascular dysfunction is considered an integral part of Alzheimer disease (AD) pathogenesis, but the possible relationship between amyloid pathology, microvascular dysfunction and cell death is still unclear. In order to investigate the influence of intraneuronal amyloid-β (Aβ) accumulation on v...

Full description

Bibliographic Details
Main Authors: Vito Antonio Baldassarro, Alessandra Marchesini, Luciana Giardino, Laura Calzà
Format: Article
Language:English
Published: The Company of Biologists 2017-05-01
Series:Disease Models & Mechanisms
Subjects:
Alzheimer's disease
Primary neurons
Intraneuronal amyloid
Oxygen glucose deprivation
Glutamate
Neurovascular coupling
Online Access:http://dmm.biologists.org/content/10/5/671

Internet

http://dmm.biologists.org/content/10/5/671

Similar Items