Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes

Oxidation of toluenes to benzaldehydes is usually accompanied by overoxidation products. Here, the authors report an iron-catalysed aerobic oxidation of methylarenes to benzaldehydes with high yields and selectivities, even in presence of boronic acid groups and in complex natural products and drugs...

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Bibliographic Details
Main Authors: Penghui Hu, Mingxi Tan, Lu Cheng, Hongyuan Zhao, Rui Feng, Wei-Jin Gu, Wei Han
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10414-7