Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

Alzheimer’s disease (AD) is the most frequent type of dementia. The pathological hallmarks of the disease are extracellular senile plaques composed of beta-amyloid peptide (Aβ) and intracellular neurofibrillary tangles composed of pTau. These findings led to the “beta-amyloid hypothesis” that propos...

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Bibliographic Details
Main Authors: Tamas Fulop, Jacek M. Witkowski, Karine Bourgade, Abdelouahed Khalil, Echarki Zerif, Anis Larbi, Katsuiku Hirokawa, Graham Pawelec, Christian Bocti, Guy Lacombe, Gilles Dupuis, Eric H. Frost
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
peripheral innate immune system
Alzheimer’s disease
infections
amyloid beta
blood–brain barrier
monocytes/macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00224/full

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00224/full

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