Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity

Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity

A compound containing an imidazole moiety and a 2,4-dienone motif with significant activity toward several fungi was discovered in a screen for new antifungal compounds. Then, a total of 26 derivatives of this compound were designed, synthesized and evaluated through in vitro and in vivo antifungal...

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Bibliographic Details
Main Authors: Chunli Liu, Ce Shi, Fei Mao, Yong Xu, Jinyan Liu, Bing Wei, Jin Zhu, Mingjie Xiang, Jian Li
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
imidazole
2,4-dienone
broad-spectrum
antifungal
antibacterial
Online Access:http://www.mdpi.com/1420-3049/19/10/15653

Internet

http://www.mdpi.com/1420-3049/19/10/15653

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