Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells

Therapeutic approaches for “sick sinus syndrome” rely on electrical pacemakers, which lack hormone responsiveness and bear hazards such as infection and battery failure. These issues may be overcome via “biological pacemakers” derived from pluripotent stem cells (PSCs). Here, we show that forward pr...

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Bibliographic Details
Main Authors: Julia Jeannine Jung, Britta Husse, Christian Rimmbach, Stefan Krebs, Juliane Stieber, Gustav Steinhoff, Andreas Dendorfer, Wolfgang-Michael Franz, Robert David
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111400085X