From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel

From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel

Background ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. KATP dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina–like symptoms, cardiovascular diseases. Methods A...

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Bibliographic Details
Main Authors:	Alfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga
Format:	Article
Language:	English
Published:	PeerJ Inc. 2018-05-01
Series:	PeerJ
Subjects:	Potassium channel ATP-sensitive inward rectifier potassium channel Binding site Homology modeling Patch clamp Molecular dynamics
Online Access:	https://peerj.com/articles/4680.pdf

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