Magnoflorine Ameliorates Inflammation and Fibrosis in Rats With Diabetic Nephropathy by Mediating the Stability of Lysine-Specific Demethylase 3A

Magnoflorine Ameliorates Inflammation and Fibrosis in Rats With Diabetic Nephropathy by Mediating the Stability of Lysine-Specific Demethylase 3A

Diabetic nephropathy (DN) represents one of the most devastating complications for patients with diabetes. The anti-diabetic activities of Magnoflorine (MF) were reported, with underlying mechanism unknown. Lysine-specific demethylase 3A (KDM3A) was identified in the renal injuries. In the current s...

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Bibliographic Details
Main Authors: Liang Chang, Qi Wang, Jiannan Ju, Yue Li, Qiao Cai, Lirong Hao, Yang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
diabetic nephropathy
magnoflorine
renal fibrosis
lysine-specific demethylase 3A
transforming growth factor β-induced factor-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.580406/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.580406/full

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