A two-phase within-host model for immune response and its application to serological profiles of pertussis

We present a simple phenomenological within-host model describing both the interaction between a pathogen and the immune system and the waning of immunity after clearing of the pathogen. We implement the model into a Bayesian hierarchical framework to estimate its parameters for pertussis using Mark...

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Bibliographic Details
Main Authors: W.F. de Graaf, M.E.E. Kretzschmar, P.F.M. Teunis, O. Diekmann
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Epidemics
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1755436514000371