Pro-Apoptotic Effects of Estetrol on Long-Term Estrogen-Deprived Breast Cancer Cells and at Low Doses on Hormone-Sensitive Cells

Purpose: Postmenopausal women with estrogen receptor-positive breast cancers often respond initially to tamoxifen or aromatase inhibitor therapy. Resistance to these treatments usually develops within 12 to 18 months. Clinical studies have demonstrated that high-dose estrogen can induce regression o...

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Bibliographic Details
Main Authors: Wei Yue, Carole Verhoeven, Herjan Coelingh Bernnink, Ji-ping Wang, Richard J Santen
Format: Article
Language:English
Published: SAGE Publishing 2019-05-01
Series:Breast Cancer: Basic and Clinical Research
Online Access:https://doi.org/10.1177/1178223419844198