The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors

The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors

Identification of novel tumor-specific targets is important for the future development of immunotherapeutic strategies using genetically engineered T cells or vaccines. In this study, we characterized the expression of VCX2, a member of the VCX/Y cancer/testis antigen family, in a large panel of nor...

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Bibliographic Details
Main Authors: Mie K. Jakobsen, Sofie Traynor, Mette Stæhr, Pascal G. Duijf, Aaraby Y. Nielsen, Mikkel G. Terp, Christina B. Pedersen, Per Guldberg, Henrik J. Ditzel, Morten F. Gjerstorff
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
VCX2
cancer/testis (CT) antigen
Immunotherapy
DNA methyl transferase (DNMT) inhibition
Histone deacetylase inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.584024/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.584024/full

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