Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver

Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver

We investigated the effects of orange juice (OJ) or hesperidin, a component of OJ, on the pharmacokinetics of pravastatin (PRV) and the expression of both protein and mRNA of multidrug resistance-associated protein 2 (Mrp2) in the rat small intestine and liver. Eight-week-old male Sprague-Dawley rat...

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Bibliographic Details
Main Authors: Minoru Watanabe, Naoki Matsumoto, Yuko Takeba, Toshio Kumai, Masami Tanaka, Shinobu Tatsunami, Sachiko Takenoshita-Nakaya, Yoshie Harimoto, Yuichi Kinoshita, Shinichi Kobayashi
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2011/502057

Internet

http://dx.doi.org/10.1155/2011/502057

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