DNA demethylation and USF regulate the meiosis-specific expression of the mouse Miwi.

Miwi, a member of the Argonaute family, is required for initiating spermiogenesis; however, the mechanisms that regulate the expression of the Miwi gene remain unknown. By mutation analysis and transgenic models, we identified a 303 bp proximal promoter region of the mouse Miwi gene, which controls...

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Bibliographic Details
Main Authors: Yu Hou, Jia Yuan, Xiang Zhou, Xiazhou Fu, Hanhua Cheng, Rongjia Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3355075?pdf=render