Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

<p>Abstract</p> <p>Background</p> <p>Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we investigated whether Sp1 t...

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Bibliographic Details
Main Authors: Jiang Feng, Zheng Xuguang, Katakowski Mark, Szalad Alexandra, Chopp Michael
Format: Article
Language:English
Published: BMC 2009-09-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:http://www.jeccr.com/content/28/1/129

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http://www.jeccr.com/content/28/1/129

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