TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

TRPM2 channels admit Ca<sup>2+</sup> and Na<sup>+</sup> across the plasma membrane and release Ca<sup>2+</sup> and Zn<sup>2+</sup> from lysosomes. Channel activation is initiated by reactive oxygen species (ROS), leading to a subsequent increase in ADP...

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Bibliographic Details
Main Authors: Eunus S. Ali, Grigori Y. Rychkov, Greg J. Barritt
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/10/8/1243