Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies

The innate immune response in the central nervous system (CNS) is implicated as both beneficial and detrimental to health. Integral to this process are microglia, the resident immune cells of the CNS. Microglia express a wide variety of pattern-recognition receptors, such as Toll-like receptors, tha...

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Bibliographic Details
Main Authors: Ian F. Caplan, Kathleen A. Maguire-Zeiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
TLR
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00417/full