Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia

Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia

The presence of aggregates of abnormally expanded polyglutamine (polyQ)-containing proteins are a pathological hallmark of a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxia-3 (SCA3). Previous studies in cellular, Drosophila, and mouse models o...

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Bibliographic Details
Main Authors: Cristy Tower, Lianwu Fu, Rachel Gill, Mark Prichard, Mathieu Lesort, Elizabeth Sztul
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
UL97
Polyglutamine
Aggresome
Ataxin 3
Huntingtin
PML bodies
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000272X

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http://www.sciencedirect.com/science/article/pii/S096999611000272X

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