Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice

Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice

The infiltration and activation of macrophages as well as lymphocytes within the aorta contribute to the pathogenesis of abdominal aortic aneurysm (AAA). Invariant natural killer T (iNKT) cells are unique subset of T lymphocytes and have a crucial role in atherogenesis. However, it remains unclear w...

Full description

Bibliographic Details
Main Authors: Akimichi Saito, Naoki Ishimori, Satoshi Tokuhara, Tsuneaki Homma, Mikito Nishikawa, Kazuya Iwabuchi, Hiroyuki Tsutsui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
obesity
natural killer T cells
mouse
macrophages
inflammation
angiotensin II
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.659418/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.659418/full

Similar Items