Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis

Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis

Abstract Background Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently, a causal link between mucus hyper-concentration and disease progressio...

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Bibliographic Details
Main Authors: Kristina Andelid, Karolina Öst, Anders Andersson, Esha Mohamed, Zala Jevnikar, Lowie E. G. W. Vanfleteren, Melker Göransson
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Respiratory Research
Subjects:
COPD
Chronic bronchitis
Sputum macrophages
Steroid resistance
TNFα
MUC5B
Online Access:https://doi.org/10.1186/s12931-021-01762-4

Internet

https://doi.org/10.1186/s12931-021-01762-4

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