Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection

Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection

Summary: T follicular helper (Tfh) cells are crucial for the establishment of germinal centers (GCs) and potent antibody responses. Nevertheless, the T cell-intrinsic factors that are required for the maintenance of already-established Tfh cells and GCs remain largely unknown. Here, we use temporall...

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Bibliographic Details
Main Authors: Dominik Alterauge, Johannes W. Bagnoli, Frank Dahlström, Barry M. Bradford, Neil A. Mabbott, Thorsten Buch, Wolfgang Enard, Dirk Baumjohann
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
Tfh cell
T helper cell
Bcl6
CXCR5
germinal center
Th1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312213

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http://www.sciencedirect.com/science/article/pii/S2211124720312213

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