Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

Abstract Microglia are the resident innate immune cells of the central nervous system. Limited turnover throughout the lifespan leaves microglia susceptible to age-associated dysfunction. Indeed, we and others have reported microglia develop a pro-inflammatory or “primed” profile with age, character...

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Bibliographic Details
Main Authors: Shane M. O’Neil, Kristina G. Witcher, Daniel B. McKim, Jonathan P. Godbout
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Acta Neuropathologica Communications
Subjects:
Microglia
Age
Priming
CSF1R antagonist
Lipopolysaccharide
RNA-Seq
Online Access:http://link.springer.com/article/10.1186/s40478-018-0636-8

Internet

http://link.springer.com/article/10.1186/s40478-018-0636-8

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