Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle

Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle

Diclofenac sodium (DCF) is a nonsteroidal anti-inflammatory drug (NSAID) and is widely used as an analgesic and anti-inflammatory agent. Herein, we found that DCF could relax high K+ (80 mM K+)-/ACh-precontracted tracheal rings (TRs) in mice. This study aimed to elucidate the underlying mechanisms o...

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Bibliographic Details
Main Authors: Chunfa Chen, Yongle Yang, Meng-Fei Yu, Shunbo Shi, Shuhui Han, Qing-hua Liu, Congli Cai, Jinhua Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
airway smooth muscle
BK channels
diclofenac sodium
relaxation
tracheal rings
voltage-dependent Ca2+ channels
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00608/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00608/full

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