Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain–associated conditions

Abstract. Introduction:. Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cl...

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Bibliographic Details
Main Authors: Maria Roitman, Laura E. Edgington-Mitchell, Jon Mangum, James Ziogas, Alexios A. Adamides, Paul Myles, Hearan Choo-Bunnett, Nigel W. Bunnett, Jenny M. Gunnersen
Format: Article
Language:English
Published: Wolters Kluwer 2019-04-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000719