Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

Abstract Background Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway epithelial cell monolayers that roflumilast, a clinically approved pho...

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Bibliographic Details
Main Authors: S. Vamsee Raju, Lawrence Rasmussen, Peter A. Sloane, Li Ping Tang, Emily Falk Libby, Steven M. Rowe
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Respiratory Research
Subjects:
CFTR
Roflumilast
cAMP
COPD
Chronic bronchitis
Online Access:http://link.springer.com/article/10.1186/s12931-017-0656-0

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http://link.springer.com/article/10.1186/s12931-017-0656-0

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