M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis. Impaired KCC2 function accelerates or facilitates seizure onset. Calpain, with two main subtypes...

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Bibliographic Details
Main Authors: Li Wan, Liang Ren, Lulan Chen, Guoxiang Wang, Xu Liu, Benjamin H. Wang, Yun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
epilepsy
calpain
KCC2
MAPK/ERK
PTZ
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00287/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00287/full

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