In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

ObjectivesRheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5-amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein/peptide antibodies (ACPAs). Citrulline is a neutral amino acid resulting from post-translational modifi...

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Bibliographic Details
Main Authors: Guillaume Larid, Mikael Pancarte, Géraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Guy Serre, Nathalie Balandraud
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
ACPA
rheumatoid arthritis
HLA-DRB1
AhFibA
citrullinated peptides 2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.692041/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.692041/full

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