Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis

Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis

Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used to treat conditions such as cutaneous T-cell lymphoma and graft-versus-host disease. However, the current procedure of ECP has limi...

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Bibliographic Details
Main Authors: Sagar Darvekar, Petras Juzenas, Morten Oksvold, Andrius Kleinauskas, Toril Holien, Eidi Christensen, Trond Stokke, Mouldy Sioud, Qian Peng
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
extracorporeal photopheresis
photodynamic therapy
cutaneous t cell lymphoma
graft-versus-host disease
5-aminolevulinic acid
8-methoxypsoralen
protoporphyrin ix
heme biosynthesis pathway
pbmc
t-cell activation
Online Access:https://www.mdpi.com/2072-6694/12/2/377

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https://www.mdpi.com/2072-6694/12/2/377

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