Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated wit...

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Bibliographic Details
Main Authors: Brandon J. Burbach, Stephen D. O’Flanagan, Qi Shao, Katharine M. Young, Joseph R. Slaughter, Meagan R. Rollins, Tami Jo L. Street, Victoria E. Granger, Lalit. K. Beura, Samira M. Azarin, Satish Ramadhyani, Bruce R. Forsyth, John C. Bischof, Yoji Shimizu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24132-6

Internet

https://doi.org/10.1038/s41467-021-24132-6

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