A Novel Application of Mixed Effects Models for Reconciling Base-Pair Resolution 5-Methylcytosine and 5-Hydroxymethylcytosine Data in Neuroepigenetics

A Novel Application of Mixed Effects Models for Reconciling Base-Pair Resolution 5-Methylcytosine and 5-Hydroxymethylcytosine Data in Neuroepigenetics

Epigenetic marks operate at multiple chromosomal levels to regulate gene expression, from direct covalent modification of DNA to three-dimensional chromosomal structure. Research has shown that 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC), are stable epigenetic mark...

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Bibliographic Details
Main Authors: Joseph Kochmanski, Candace Savonen, Alison I. Bernstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Genetics
Subjects:
neuroepigenetics
mixed effects model for repeated measures
5-methylcytosine
5-hydroxymethylcytosine
bioinformatics
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00801/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00801/full

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