ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in individuals on combined antiretroviral therapy (cART) with undetectable viremia. In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machiner...

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Bibliographic Details
Main Authors: Juan Zhao, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Xindi Dang, Dechao Cao, Sushant Khanal, Madison Schank, Bal Krishna Chand Thakuri, Stella C. Ogbu, Zheng D. Morrison, Xiao Y. Wu, Zhengke Li, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
ATM
apoptosis
DNA damage repair
immune aging
HIV
T cell homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02531/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02531/full

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