Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts

Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts

Abstract Background Oral squamous cell carcinoma (OSCC) invades surrounding tissues by upregulating matrix metalloproteinases (MMPs) -2 and −9, which causes over-expression of the Hedgehog signaling proteins Shh and Gli-1 and degradation of the extracellular matrix, thereby creating a “highway” for...

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Bibliographic Details
Main Authors: Haixia Fan, Haixia Li, Guanyao Liu, Wei Cong, Hong Zhao, Wenwu Cao, Jinhua Zheng
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Oral squamous cancer cells
Doxorubicin
Ultrasound
MMP-2/9
Hedgehog signaling pathway
Online Access:http://link.springer.com/article/10.1186/s13046-017-0633-y

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http://link.springer.com/article/10.1186/s13046-017-0633-y

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