Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers

Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers

Abstract Background Diverse vaccination outcomes and protection levels among different populations pose a serious challenge to the development of an effective malaria vaccine. Co-infections are among many factors associated with immune dysfunction and sub-optimal vaccination outcomes. Chronic, asymp...

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Bibliographic Details
Main Authors: Anneth-Mwasi Tumbo, Tobias Schindler, Jean-Pierre Dangy, Nina Orlova-Fink, Jose Raso Bieri, Maximillian Mpina, Florence A. Milando, Omar Juma, Ali Hamad, Elizabeth Nyakarungu, Mwajuma Chemba, Ali Mtoro, Kamaka Ramadhan, Ally Olotu, Damas Makweba, Stephen Mgaya, Kenneth Stuart, Matthieu Perreau, Jack T. Stapleton, Said Jongo, Stephen L. Hoffman, Marcel Tanner, Salim Abdulla, Claudia Daubenberger
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Virology Journal
Subjects:
Malaria
Human pegivirus
Controlled human malaria infection
Immune activation
Antibody response
PfSPZ vaccine
Online Access:https://doi.org/10.1186/s12985-021-01500-8

Internet

https://doi.org/10.1186/s12985-021-01500-8

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