A Practical Approach to Immunotherapy of Hepatocellular Carcinoma Using T Cells Redirected Against Hepatitis B Virus

A Practical Approach to Immunotherapy of Hepatocellular Carcinoma Using T Cells Redirected Against Hepatitis B Virus

Hepatocellular carcinoma (HCC) cells often have hepatitis B virus (HBV)-DNA integration and can be targeted by HBV-specific T cells. The use of viral vectors to introduce exogenous HBV-specific T-cell receptors (TCR) on T cells to redirect their specificity is complex and expensive to implement in c...

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Bibliographic Details
Main Authors: Sarene Koh, Noriko Shimasaki, Rossarin Suwanarusk, Zi Zong Ho, Adeline Chia, Nasirah Banu, Shanshan Wu Howland, Alice Soh Meoy Ong, Adam J Gehring, Hans Stauss, Laurent Renia, Matti Sällberg, Dario Campana, Antonio Bertoletti
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
hepatitis B virus
hepatocellular carcinoma
mRNA electroporation
TCR gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301755

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http://www.sciencedirect.com/science/article/pii/S2162253116301755

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