Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling

Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling

Background: Islet autophagy plays a role in glucose/lipid metabolism in type 2 diabetes mellitus. Meanwhile, fibroblast growth factor 21 (FGF21) has been found to regulate insulin sensitivity and glucose homeostasis. Whether FGF21 induces islet autophagy, remains to be elucidated. This study aimed t...

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Bibliographic Details
Main Authors: Sam Tsz Wai Cheng, Stephen Yu Ting Li, Po Sing Leung
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes mellitus
islet autophagy
FGF21
CVX343
Online Access:https://www.mdpi.com/1422-0067/20/10/2517

Internet

https://www.mdpi.com/1422-0067/20/10/2517

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