Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA

Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA

Abstract Background Enterobacterial common antigen (ECA) is a family-specific surface antigen shared by all members of the Enterobacteriaceae family. Previous studies showed that the loss of ECA results in Salmonella attenuation, indicating its usefulness as a vaccine candidate for Salmonella infect...

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Bibliographic Details
Main Authors: Qing Liu, Xuegang Shen, Xiaoping Bian, Qingke Kong
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Microbiology
Subjects:
ECA
Salmonella Typhimurium
Virulence
Vaccine vector
Th2 immunity
Online Access:http://link.springer.com/article/10.1186/s12866-020-01837-0

Internet

http://link.springer.com/article/10.1186/s12866-020-01837-0

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