Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed

Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed

HTRA2 is a mitochondrial protein, mutations in which are associated with autosomal dominant late-onset Parkinson’s disease (PD). The mechanisms by which HTRA2 mutations result in PD are poorly understood. HTRA2 is proposed to play a proteolytic role in protein quality control and homeostasis in the...

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Bibliographic Details
Main Authors: Suwei Chen, Oana Sanislav, Sarah J. Annesley, Paul R. Fisher
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Genes
Subjects:
HTRA2
Parkinson’s disease
Dictyostelium
endocytosis
growth
mitochondria
phototaxis
Online Access:http://www.mdpi.com/2073-4425/9/7/355

Internet

http://www.mdpi.com/2073-4425/9/7/355

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