Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress

The Yeast Knockout (YKO) collection has provided a wealth of functional annotations from genome-wide screens. An unintended consequence is that 76% of gene annotations derive from one genotype. The nutritional auxotrophies in the YKO, in particular, have phenotypic consequences. To address this issu...

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Bibliographic Details
Main Authors: Erica Acton, Amy Huei-Yi Lee, Pei Jun Zhao, Stephane Flibotte, Mauricio Neira, Sunita Sinha, Jennifer Chiang, Patrick Flaherty, Corey Nislow, Guri Giaever
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160330