lncRNA requirements for mouse acute myeloid leukemia and normal differentiation

lncRNA requirements for mouse acute myeloid leukemia and normal differentiation

A substantial fraction of the genome is transcribed in a cell-type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here, we systematically characterize transcriptional dynamics during hematopoiesis and in hematological malignancies. Our analysis of...

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Bibliographic Details
Main Authors: M Joaquina Delás, Leah R Sabin, Egor Dolzhenko, Simon RV Knott, Ester Munera Maravilla, Benjamin T Jackson, Sophia A Wild, Tatjana Kovacevic, Eva Maria Stork, Meng Zhou, Nicolas Erard, Emily Lee, David R Kelley, Mareike Roth, Inês AM Barbosa, Johannes Zuber, John L Rinn, Andrew D Smith, Gregory J Hannon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
lncRNA
hematopoiesis
leukemia
c-Myc
Online Access:https://elifesciences.org/articles/25607

Internet

https://elifesciences.org/articles/25607

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