Facile synthesis of insulin fusion derivatives through sortase A ligation

Facile synthesis of insulin fusion derivatives through sortase A ligation

Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to retain insulin bioactivity. New and efficient metho...

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Bibliographic Details
Main Authors: Maria M. Disotuar, Jake A. Smith, Jinze Li, Steve Alam, Nai-Pin Lin, Danny Hung-Chieh Chou
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Diabetes mellitus
Insulin synthesis
Sortase A (SrtA) ligation
Albumin-binding peptide SA21
Long-acting insulin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308017

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http://www.sciencedirect.com/science/article/pii/S2211383520308017

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