DDR-mediated crosstalk between DNA-damaged cells and their microenvironment

DDR-mediated crosstalk between DNA-damaged cells and their microenvironment

The DNA damage response (DDR) is an evolutionarily conserved signaling cascade that senses and responds to double-strand DNA breaks by organizing downstream cellular events, ranging from appropriate DNA repair to cell cycle checkpoints. In higher organisms, the DDR prevents neoplastic transformation...

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Bibliographic Details
Main Authors: Nicolas eMalaquin, Audrey eCarrier-Leclerc, Mireille eDessureault, Francis eRodier
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Genetics
Subjects:
Bystander Effect
Inflammation
senescence
microenvironment
DNA damage response
Tissue damage
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00094/full

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