Treatment estimands in clinical trials of patients hospitalised for COVID-19: ensuring trials ask the right questions

Treatment estimands in clinical trials of patients hospitalised for COVID-19: ensuring trials ask the right questions

Abstract When designing a clinical trial, explicitly defining the treatment estimands of interest (that which is to be estimated) can help to clarify trial objectives and ensure the questions being addressed by the trial are clinically meaningful. There are several challenges when defining estimands...

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Bibliographic Details
Main Authors: Brennan C. Kahan, Tim P. Morris, Ian R. White, Conor D. Tweed, Suzie Cro, Darren Dahly, Tra My Pham, Hanif Esmail, Abdel Babiker, James R. Carpenter
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Medicine
Subjects:
COVID-19
Estimand
Randomised trial
Intercurrent events
Truncation-by-death
Online Access:http://link.springer.com/article/10.1186/s12916-020-01737-0

Internet

http://link.springer.com/article/10.1186/s12916-020-01737-0

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