FAM111A protects replication forks from protein obstacles via its trypsin-like domain

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication forks.

Bibliographic Details
Main Authors: Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15170-7

Internet

https://doi.org/10.1038/s41467-020-15170-7

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