Polymeric siRNA delivery targeting integrin-β1 could reduce interactions of leukemic cells with bone marrow microenvironment

Polymeric siRNA delivery targeting integrin-β1 could reduce interactions of leukemic cells with bone marrow microenvironment

Uncontrolled proliferation of the myeloid cells due to BCR-ABL fusion has been successfully treated with tyrosine kinase inhibitors (TKIs), which improved the survival rate of Chronic Myeloid Leukemia (CML) patients. However, due to interactions of CML cells with bone marrow microenvironment, sub-po...

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Bibliographic Details
Main Authors: Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Remant Bahadur KC, Ibrahim Oğuzhan Tarman, Hasan Uludağ
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomaterials and Biosystems
Subjects:
Chronic myeloid leukemia
RNAi
siRNA delivery
Integrin-β1
Polyethyleneimine
Fibronectin binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2666534421000143

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http://www.sciencedirect.com/science/article/pii/S2666534421000143

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