Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Mexiletine (Mex) has been recently appointed as an orphan-drug in myotonic-syndromes, being a potent use-dependent blocker of skeletal-muscle sodium channels (NaV1.4). Available evidences about a potential anti-oxidant effect of Mex and its tetramethyl-pyrroline-derivatives in vivo, suggest the poss...

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Bibliographic Details
Main Authors: Michela De Bellis, Francesca Sanarica, Alessia Carocci, Giovanni Lentini, Sabata Pierno, Jean-François Rolland, Diana Conte Camerino, Annamaria De Luca
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
voltage-clamp recordings
sodium channel
skeletal muscle
anti-myotonic agent
muscular dystrophy
mexiletine
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00907/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00907/full

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