Infection-derived lipids elicit an immune deficiency circuit in arthropods

Infection-derived lipids elicit an immune deficiency circuit in arthropods

The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.

Bibliographic Details
Main Authors: Dana K. Shaw, Xiaowei Wang, Lindsey J. Brown, Adela S. Oliva Chávez, Kathryn E. Reif, Alexis A. Smith, Alison J. Scott, Erin E. McClure, Vishant M. Boradia, Holly L. Hammond, Eric J. Sundberg, Greg A. Snyder, Lei Liu, Kathleen DePonte, Margarita Villar, Massaro W. Ueti, José de la Fuente, Robert K. Ernst, Utpal Pal, Erol Fikrig, Joao H. F. Pedra
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14401

Internet

https://doi.org/10.1038/ncomms14401

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